4.8 Article

Ru(CO)-salen-Catalyzed Synthesis of Enantiopure Aziridinyl Ketones and Formal Asymmetric Synthesis of (+)-PD 128907

Journal

ORGANIC LETTERS
Volume 14, Issue 17, Pages 4658-4661

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol302095r

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Funding

  1. Nissan Chemical Industries, Ltd.
  2. World Premier International Research Center Initiative (WPI)
  3. JSPS KAKENHI from MEXT, Japan [23245009]
  4. Grants-in-Aid for Scientific Research [23245009] Funding Source: KAKEN

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Aziridination of vinyl ketones using SESN3 in the presence Ru(CO)-salen complex 1 provides the enantiopure aziridinyl ketones that can serve as useful chiral building blocks. A formal asymmetric synthesis of (+)-PD 128907 was achieved in an eight-step sequence via aziridination.

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