Journal
ORGANIC LETTERS
Volume 14, Issue 17, Pages 4534-4536Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol3020094
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- Amgen
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Epidithiodiketopiperazines (ETPs) are natural products (e.g., gliotoxin) with varied and important biological activity, which often is attributed to the redox properties of the disulfide moiety. As such, analogs with altered redox properties and similar structural characteristics would be of value to biological investigations. The use of an ETP as the point of departure in the first synthesis of an epidiselenodiketopiperazine (ESeP) and its activity against Mycobacterium tuberculosis (MTB) is reported.
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