Journal
ORGANIC LETTERS
Volume 15, Issue 2, Pages 398-401Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol303388k
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- National Institutes of Health [GM 74776]
- Stony Brook University
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A 12-step synthesis of kingianin A, an inhibitor of the antiapoptotic protein Bcl-xL, Is based on a radical cation Diels-Alder reaction (RCDA). This approach is thought to be biomimetic. The use of a tether in the key RCDA step controls the regiochemistry of the cycloaddition, leading to the desired core structure and a separable diastereomer.
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