Journal
ORGANIC LETTERS
Volume 14, Issue 5, Pages 1290-1293Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol300182r
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- Uehara Memorial Foundation
- Society of Synthetic Organic Chemistry, Japan (Meiji Seika Award in Synthetic Organic Chemistry, Japan)
- Suntory Institute for Bioorganic Research (SUNBOR)
- Grants-in-Aid for Scientific Research [23102014, 21510221, 23310148] Funding Source: KAKEN
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A hybrid compound consisting of aplyronine A and mycalolide B was synthesized, and its biological activities were evaluated. The hybrid compound was found to have somewhat more potent actin-depolymerizing activity than aplyronine A. In contrast, the hybrid compound possessed about 1000-fold less cytotoxicity than aplyronine A. These results indicated that there is no direct correlation between actin-depolymerizing activity and cytotoxicity.
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