4.8 Article

Copper-Catalyzed Alkylation of Benzoxazoles with Secondary Alkyl Halides

Journal

ORGANIC LETTERS
Volume 14, Issue 7, Pages 1748-1751

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol300348w

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Funding

  1. Swiss National Science Foundation [20021_126498]

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Copper-catalyzed direct alkylation of benzoxazoles using nonactivated secondary alkyl halides has been developed. The best catalyst is a new copper(I) complex (1), and the reactions are promoted by bis[2-(N,N-dimethylamino)ethyl] ether.

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