4.8 Article

N-Directing Group Assisted Rhodium-Catalyzed Aryl C-H Addition to Aryl Aldehydes

Journal

ORGANIC LETTERS
Volume 14, Issue 2, Pages 636-639

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol2032784

Keywords

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Funding

  1. MOST of China [2009CB-825300]
  2. NSFC [20821062, 20925207, 21002001]

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Direct aryl C-H addition to aryl aldehydes to produce biaryl methanols was reported via Rh catalysis with an N-containing directing group. The method is highly atom-, step-, and redox-economic. The procedure is robust, reliable, and compatible with water and air.

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