4.8 Article

From Spirolactam Mixtures to Regioisomerically Pure 5-and 6-Rhodamines: A Chemodosimeter-Inspired Strategy

Journal

ORGANIC LETTERS
Volume 14, Issue 8, Pages 2014-2017

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol300523m

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Funding

  1. National Natural Science Foundation of China [21174022]
  2. Specialized Research Fund for the Doctoral Program of Higher Education [20110041110009]

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Inspired by the ring-open reaction of rhodamine spriolactams as typical chemodosimeters, a general strategy is proposed to conveniently and efficiently synthesize isomerically pure 5- and 6-R-tetramethylrhodamine on a larger scale.

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