Journal
ORGANIC LETTERS
Volume 14, Issue 9, Pages 2402-2405Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol300831t
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Funding
- Australian Research Council [DP110100112]
- National Computing Infrastructure (NCI) facility
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The first total synthesis of mycocyclosin, a diketopiperazine natural product isolated from M. tuberculosis, is described. While direct oxidative coupling of tyrosine phenolic groups was unsuccessful, construction of the highly strained bicyclic framework was successfully accomplished through an intramolecular Miyaura-Suzuki cross-coupling to generate the biaryl linkage.
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