4.8 Article

Construction of the Azocane (Azacyclooctane) Moiety of the Lycopodium Alkaloid Lycopladine H via an Intramolecular Hydroaminomethylation Strategy

Journal

ORGANIC LETTERS
Volume 14, Issue 8, Pages 2172-2175

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol3007277

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Funding

  1. National Science Foundation [CHE-1105653]
  2. Direct For Mathematical & Physical Scien
  3. Division Of Chemistry [1105653] Funding Source: National Science Foundation

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An efficient synthetic strategy has been developed for annulation of an azocane ring onto a bicyclo[2.2.2]octane scaffold via an intramolecular hydroaminomethylation protocol to generate an advanced intermediate bearing three of the four rings of the structurally unique Lycopodium alkaloid lycopladine H (1).

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