Journal
ORGANIC LETTERS
Volume 14, Issue 8, Pages 1994-1997Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol3004589
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Funding
- National Natural Science Foundation of China [41076084, 20975094]
- Changjiang Scholars and Innovative Research Team in University (PCSIRT) [IRT0944]
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Suberitine A-D (1-4), four new bis-aaptamine alkaloids with two aaptamine skeleton units, 8,9,9-trimethoxy-9H-benzo[de][1,6]-naphthyridine and demethyl(oxy)-aaptamine, linked through a rare C-3-C-3' or C-3-C-6' sigma-bond between the 1,6-naphthyridine rings, together with two known monomers 5 and 6, were isolated from the marine sponge Aaptos suberitoides. Their structures were elucidated using NMR spectroscopy. Compounds 2 and 4 showed potent cytotoxicity against P388 cell lines, with IC50 values of 1.8 and 3.5 mu M, respectively.
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