Journal
ORGANIC LETTERS
Volume 14, Issue 24, Pages 6154-6157Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol3028303
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- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2012-0001488]
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Densanins A (1) and B (2) were isolated from the sponge Haliclona densaspicula. On the basis of spectral data and the Mosher ester method, the complete structures were characterized as hexacyclic diamine alkaloids, which were probably derived from 3-alkylpyridine. Compounds 1 and 2 showed relatively potent inhibitory effects on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells with IC50 values of 1.05 and 2.14 mu M, respectively.
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