4.8 Article

Toward the Total Synthesis of Palhinine A: Expedient Assembly of Multifunctionalized Isotwistane Ring System with Contiguous Quaternary Stereocenters

Journal

ORGANIC LETTERS
Volume 14, Issue 14, Pages 3696-3699

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol301534r

Keywords

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Funding

  1. NSFC [20802030, 21072082, 20921120404]
  2. MOST [2010CB833200]
  3. Fok Ying Tung Education Foundation [121015]
  4. Chinese Ministry of Education [109154]
  5. PCSIRT [IRT1138]
  6. NCET [NCET-08-0254]
  7. MOE [111-2-17]
  8. Fundamental Research Funds for the Central Universities [lzujbky-2010-k09, lzujbky-2012-k39]
  9. Lanzhou University

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The stereoselective, expedient assembly of the key functionalized isotwistane (bridged tricyclo[4.3.1.0(3,7)]decane) system, 5/6/6 ring, with contiguous quaternary stereocenters in Lycopodium alkaloid palhinine A and its analogues via an intramolecular Diels-Alder strategy is described.

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