4.8 Article

Synthesis of α,γ-Peptide Hybrids by Selective Conversion of Glutamic Acid Units

Journal

ORGANIC LETTERS
Volume 14, Issue 13, Pages 3542-3545

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol301552c

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Funding

  1. Research Program of the Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica, Ministerio de Ciencia e Innovacion/Economia y Competitividad, Spain [CTQ2009-07109]
  2. FEDER funds
  3. ACIISI (Gobierno de Canarias)

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The site-selective modification of small peptides at a glutamate residue allows the ready preparation of alpha,gamma-hybrids. In this way, a single peptide can be transformed into a variety of hybrid derivatives. The process takes place under very mild conditions, and good global yields are obtained.

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