4.8 Article

Intramolecular Alkene Electrophilic Bromination Initiated ipso-Bromocyclization for the Synthesis of Functionalized Azaspirocyclohexadienones

Journal

ORGANIC LETTERS
Volume 14, Issue 13, Pages 3526-3529

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol301531z

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Funding

  1. National Basic Research Program of China (973 Program) [2009CB825300]
  2. National Natural Science Foundation of China [20923005, 21025209, 21121062]
  3. Chinese Academy of Sciences

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Intramolecular alkene electrophilic bromination initiated dearomative cyclization has been realized in the presence of DBDMH to provide functionalized azaspirocyclohexadienones in excellent yields under mild conditions.

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