Journal
ORGANIC LETTERS
Volume 14, Issue 24, Pages 6158-6161Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol302842h
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Funding
- National Natural Science Foundation of China
- National Basic Research Program of China (973 Program) [2012CB821600]
- Ministry of Education of China [B06005]
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A highly efficient asymmetric hydrogenation of alpha-substituted alpha,beta-unsaturated acyclic ketones catalyzed by chiral spiro iridium complexes for the preparation of chiral 2-substituted allylic alcohols has been developed (ee up to 99.7%). This method provides a concise route to (-)-mesembrine (34% yield, 12 steps).
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