Journal
ORGANIC LETTERS
Volume 14, Issue 23, Pages 5840-5843Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol302691j
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Funding
- National Institutes of Health [GM-33328-21, GM-081546-04]
- Swiss National Science Foundation
- Novartis Foundation
- DAAD
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A new approach to the tetracycline core structure is presented. The pivotal intermediate is identified as macrocycle III. The two interior bonds (C4a-C12a and C5a-C11a) are to be constructed through sequential transannular Michael additions (III-II) and compression-promoted transannular isoxazole alkylations from intermediate II.
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