4.8 Article

Three-Component Reaction of Propargyl Amines, Sulfonyl Azides, and Alkynes: One-Pot Synthesis of Tetrasubstituted Imidazoles

Journal

ORGANIC LETTERS
Volume 14, Issue 24, Pages 6266-6269

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol303023y

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Funding

  1. National Nature Science Foundation of China [20972137, 21032005]

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An efficient and straightforward strategy for the synthesis of tetrasubstituted imidazoles from propargyl amines, sulfonyl azides, and terminal alkynes is described. N-Sulfonyl ketenimine and aminoallene are believed to be the key intermediates for this two-step one-pot transformation.

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