Journal
ORGANIC LETTERS
Volume 14, Issue 22, Pages 5640-5643Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol302483f
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Funding
- NCET [10-0371]
- NSFC [21072063]
- SRF for ROCS [2010-1174]
- RFDP [20100172120020]
- GNSF [10351064101000000]
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A novel cascade cyclization of ethyl glyoxalate and amines proceeds in the presence of Pd(TFA)(2) (5 mol %) to give the cyclic dehydro-a-amino acid derivatives. This method provides a fast and simple access to highly substituted dihydro-pyrrol-2-ones in good yields.
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