4.8 Article

Palladium-Catalyzed C-H Functionalization Using Guanidine as a Directing Group: Ortho Arylation and Olefination of Arylguanidines

Journal

ORGANIC LETTERS
Volume 14, Issue 21, Pages 5452-5455

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol302533w

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Funding

  1. National Natural Science Foundation of China [81072516]
  2. Natural Science Foundation of Zhejiang Province [Z2110655]
  3. National Institute on Drug Abuse [DA031370]
  4. State of Florida, Executive Office of the Governor's Office of Tourism, Trade, and Economic Development

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Palladium-catalyzed C-H functionalization using guanidine as the directing group was achieved under mild reaction conditions. Various guanidine derivatives were produced in moderate to good yields by using simple unactivated arenes or ethyl acrylate as the source of arylation or olefination, respectively.

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