4.8 Article

Palladium-Catalyzed Direct Arylation of Imidazolone N-Oxides with Aryl Bromides and Its Application in the Synthesis of GSK2137305

Journal

ORGANIC LETTERS
Volume 14, Issue 7, Pages 1872-1875

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol300468g

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The palladium-catalyzed direct arylation of imidazolone N-oxides with aryl bromides to afford the corresponding 4-aryl imidazolone N-oxides is described. This method has been successfully used for the synthesis of GSK2137305.

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