Journal
ORGANIC LETTERS
Volume 14, Issue 13, Pages 3462-3465Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol301431d
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Funding
- Japan Society for the Promotion of Science (JSPS) [24750081, 23390001]
- Ministry of Education, Culture, Sports, Science and Technology, Japan [23105501]
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [23390001, 24750081] Funding Source: KAKEN
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One of the most challenging transformations in current organic chemistry is the catalytic carboxylation of a C(sp(3))-H bond using CO2 gas, an inexpensive and ubiquitous Cl source. A sequential protocol for C(sp(3))-H carboxylation by employing a nitrogen-directed, metal-assisted, C-H activation/catalytic silylation reaction in conjunction with fluoride-mediated carboxylation with CO2 was established. The carboxylation proceeded only at the benzylic C(sp(3))-Si bond, not at the aromatic C(sp(2))-Si, which is advantageous for further manipulations of the products.
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