4.8 Article

Asymmetric Pericyclic Cascade Approach to Spirocyclic Oxindoles

Journal

ORGANIC LETTERS
Volume 14, Issue 11, Pages 2762-2765

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol300982f

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Funding

  1. Royal Society
  2. Leverhulme Trust
  3. Cancer Research UK
  4. Cancer Research UK [6950] Funding Source: researchfish

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The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90-99% ee) via a pericyclic cascade process.

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