Journal
ORGANIC LETTERS
Volume 15, Issue 1, Pages 100-103Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol3031318
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Funding
- Marine Biotechnology Program, Ministry of Land, Transport and Maritime Affairs
- BK21 program, Ministry of Education, Science and Technology, Korea
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Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B (1-2), were isolated from a Korean marine sponge Placospongia sp. Their structures were elucidated by spectroscopic data analysis. Phosphoiodyn A exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta (hPPAR delta) with an EC50 of 23.7 nM.
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