Journal
ORGANIC LETTERS
Volume 14, Issue 23, Pages 5964-5967Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol302875x
Keywords
-
Categories
Funding
- Welch Foundation [E-1571]
- NIGMS [R01GM077635]
- A. P. Sloan Foundation
- Camille and Henry Dreyfus Foundation
Ask authors/readers for more resources
A method for direct, transition-metal-free ortho-arylation of anilines by aryl chlorides, bromides, fluorides, and triflates has been developed. This methodology provides the most direct approach to 2-arylanilines since no protecting or directing groups on nitrogen are required. The arylation is functional-group tolerant, with alkene, ether, trifluoromethyl, dimethylamino, carbonyl, chloro, and cyano functionalities tolerated. Phenylation of enantiopure binaphthyldiamine affords a product with >99% ee.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available