Soluble-support-assisted Electrochemical Reactions: Application to Anodic Disulfide Bond Formation

A soluble-support-assisted technique was successfully applied to electrochemical reactions, leading to anodic disulfide bond formation. The support-bound peptide was soluble in electrolyte solution, allowing electron transfer at the surface of the electrodes. After completion of the reaction, the support-bound product was recovered as a precipitate by simple dilution of the reaction mixture with poor solvent.