4.8 Article

An Organic Molecule Modulated Chemoselective Cyclization of Alkynyl Nitriles Tethered to 2-Alkyl Substituted Chromones with Multireactive Sites

Journal

ORGANIC LETTERS
Volume 14, Issue 24, Pages 6122-6125

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol302964x

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Funding

  1. National Natural Science Foundation of China [21172232]
  2. Ministry of Science and Technology of China [2009CB940903]

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A small organic molecule phenylacetonitrile promoted chemoselective cyclization of (chromen-3-yl)alkynylnitriles to generate a novel tetracyclic or tricyclic chromone scaffold has been discovered. Importantly, the phenylacetonitrile serves as an anion transfer reagent changing the normal reaction of the substrate.

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