4.8 Article

Benzofurans or Isochromenes via the Ring-Opening Cyclization of Cyclopropene Derivatives with Organolithiums

Journal

ORGANIC LETTERS
Volume 14, Issue 3, Pages 720-723

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol2032009

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Funding

  1. National Natural Science Foundation of China [21172192]
  2. National Basic Research Program of China [2011CB808700]

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A new and efficient approach to benzocycles from cyclopropene derivatives is described. Deprotection by organolithiums and subsequent ring-opening cyclization of the related 2-cyclopropenyl phenyl or benzyl acetates generated benzofurans and isochromenes in one pot.

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