4.8 Article

Palladium-Catalyzed Cross-Coupling of H-Phosphinate Esters with Chloroarenes

Journal

ORGANIC LETTERS
Volume 13, Issue 12, Pages 3270-3273

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol201222n

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Funding

  1. National Science Foundation [CHE-0953368]

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The palladium-catalyzed cross-coupling reaction between H-phosphinate esters and chloroarenes or chloroheteroarenes Is described. This reaction is the first general metal-catalyzed phosphorus carbon bond-forming reaction between a phosphorus nucleophile and chloroarenes.

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