Journal
ORGANIC LETTERS
Volume 13, Issue 5, Pages 1250-1253Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol2001705
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Funding
- The University of Bath
- EPSRC [EP/E017495/1]
- Engineering and Physical Sciences Research Council [EP/E017495/1] Funding Source: researchfish
- EPSRC [EP/E017495/1] Funding Source: UKRI
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The design, synthesis, and study of a helical dialkylaminopyridine Lewis base catalyst is reported. Helical DMAP analogue 4 is based upon a helicenoid structure and displays good to excellent levels of selectivity (S <= 116) in the kinetic resolution of chiral secondary alcohols. Catalyst 4 displays excellent reactivity with exceptionally low loadings of 0.05 mol % effecting practical levels of selectivity in kinetic resolutions.
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