Journal
ORGANIC LETTERS
Volume 13, Issue 6, Pages 1274-1277Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol1030266
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Funding
- National Natural Science Foundation of China [20972083]
- Ministry of Science and Technology of China [2009ZX09501-004]
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An efficient copper-catalyzed approach to quinazolinone derivatives has been developed, and the protocol uses cheap and readily available substituted 2-halobenzamides and (aryl)methanamines as the starting materials as well as economical and environmentally friendly air as the oxidant. This can be the first example of constructing N-heterocycles via sequential Ullmann-type coupling under air and aerobic oxidative C-H amidation.
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