4.8 Article

Cell-Permeable Iminocoumarine-Based Fluorescent Dyes for Mitochondria

Journal

ORGANIC LETTERS
Volume 13, Issue 11, Pages 2884-2887

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol200908r

Keywords

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Funding

  1. National Natural Science Foundation of China [20721003, 20872153, 81025017, 30870513, 31070680]
  2. National S&T Major Projects [2009ZX09301-001, 2009ZX09501-001, 2009ZX09501-010, 2009ZX09102-114, 2009ZX09301-011]

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A class of small molecule fluorophores, 2-iminocoumarin-3-carboxamide derivatives, has been developed by a rapid microwave-assisted process. These fluorescent probes are cell membrane permeable with low cytotoxicity and able to selectively stain organelles in living cells.

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