4.8 Article

Copper-Catalyzed Synthesis of Quinoxalines with o-Phenylenediamine and Terminal Alkyne in the Presence of Bases

Journal

ORGANIC LETTERS
Volume 13, Issue 17, Pages 4514-4517

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol201664x

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Funding

  1. Scientific Research Foundation for the State Education Ministry [107108]
  2. National Science Foundation of P. R. China [J0730425]

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A novel way of synthesizing quinoxalines efficiently through cyclization of o-phenylenediamine and terminal alkyne by Cu(II) and bases is developed. This reaction proceeds smoothly to give the products in moderate to good yields.

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