4.8 Article

Palladium-Catalyzed Domino C-S Coupling/Carbonylation Reactions: An Efficient Synthesis of 2-Carbonylbenzo[b]thiophene Derivatives

Journal

ORGANIC LETTERS
Volume 13, Issue 11, Pages 2868-2871

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol200880m

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Funding

  1. Natural Sciences and Engineering Research Council of Canada (NSERC)

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A facile and selective palladium-catalyzed domino procedure has been developed for the preparation of 2-carbonylbenzo[b]thiophene derivatives from 2-gem-dihalovinylthiophenols. This protocol involves intramolecular C-S coupling/intermolecular carbonylation cascade sequences and allows access to various highly functionalized benzo[b]thiophenes in moderate yields.

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