Journal
ORGANIC LETTERS
Volume 13, Issue 18, Pages 4850-4853Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol201930e
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Funding
- Pennsylvania State University
- NSF [CHE-1055795]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1055795] Funding Source: National Science Foundation
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A highly efficient and generally applicable method has been developed to functionalize the ortho-C(sp(2)) H bonds of picolinamide (PA)-protected benzylamine substrates with a broad range of beta-H-containing alkyl halides. Sodium triflate has been identified as a critical promoter for this reaction system. The PA group can be easily installed and removed under mild conditions. This method provides a new strategy to prepare highly functionalized benzylamines for the synthesis of complex molecules.
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