4.8 Article

Regiospecific Synthesis of 1,2-Disubstituted (Hetero)aryl Fused Imidazoles with Tunable Fluorescent Emission

Journal

ORGANIC LETTERS
Volume 13, Issue 24, Pages 6516-6519

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol202807d

Keywords

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Funding

  1. National NSF of China [21025205, 20972102, 21021001, 20872101]
  2. PCSIRT [IRT0846]
  3. National Basic Research Program of China (973 Program) [2011CB808600]

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A palladium-catalyzed two or fourfold amination was established that allows regiospecific synthesis of a diversity-oriented library of 1,2-disubstituted (hetero)aryl fused imidazoles, and provides an exceptional tool for the discovery of fluorescent scaffolds with tunable fluorescence emission. These fluorophores have been applied as fluorescent probes for live cell imaging.

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