Journal
ORGANIC LETTERS
Volume 13, Issue 19, Pages 5386-5389Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol202281h
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Funding
- National Natural Science Foundation of China [20872026]
- Hi-Tech Research and Development Program of China (863 Plan) [2009AA02Z308]
- Shanghai Pujiang Talent Plan Project [09PJD008]
- National Basic Research Program of China (973 Program) [2010CB912600]
- Sino Swiss Science and Technology Cooperation (SSSTC) [EG 30-032010]
- Roche R&D Center (China) Ltd.
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Microwave-assisted iridium catalyzed alkylation of amines with alcohols was undertaken under solvent-free and base-free conditions. Such alkylation reactions are green, atom-economic, and effective for mono-, di-, and triaklyation of amines. Good isolated yields were obtained for mono- and dialkylated amines using stoichiometric amounts of amines and alcohols, in the presence of 1 mol % [Cp*IrCl2](2). Reasonable yields of trialkylated products were obtained using 4 equiv of alcohols.
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