Journal
ORGANIC LETTERS
Volume 13, Issue 6, Pages 1378-1381Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol200065s
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The novel Pd-catalyzed C(sp(2))-H/C(sp(2)) H cross-coupling of unactivated xanthines with unactivated arenes utilizing a combination of Ag(I) and O(2) as oxidants exclusively yields C-8 arylated xanthines in a single synthetic operation.
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