Journal
ORGANIC LETTERS
Volume 14, Issue 2, Pages 513-515Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol203097b
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Funding
- Ministry of Education, Science, Sports and Culture of Japan [23710248, 23590582]
- A-STEP (FS-stage) from Japan Science and Technology Agency (JST) [AS221Z01739G]
- Uehara Memorial Foundation
- Japan Association for Chemical Innovation
- Grants-in-Aid for Scientific Research [23710248, 24590310, 23651212, 23590582] Funding Source: KAKEN
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The concomitant addition of the histone deacetylase inhibitor and the DNA methyltransferase inhibitor to the culture medium of an entomopathogenic fungus, Isaria tenuipes, greatly enhanced its secondary metabolite production and led to the isolation of tenuipyrone (1), a novel polyketide with an unprecedented tetracyclic ring system bearing a spiroketal structural component, along with two known C-10-polyketides, cephalosporolide B (2), which is a plausible biosynthetic precursor of 1, and cephalosporolide F (3).
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