Journal
ORGANIC LETTERS
Volume 13, Issue 7, Pages 1662-1665Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol2001039
Keywords
-
Categories
Funding
- Tatematsu Foundation
Ask authors/readers for more resources
Enantiomerically enriched trihalomethyl-substituted alcohols having a quaternary chiral carbon center can be prepared by the catalytic enantioselective cross-aldol reaction of acetone with trihalomethyl ketones by using N-(8-quinolinesulfonyl)prolinamide as an organocatalyst. The MO calculations elucidate that the hydrogen bonding between the sulfonimide proton and the 8-quinolyl nitrogen atom plays an important role in exerting the enantioselectivity of the reaction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available