Journal
ORGANIC LETTERS
Volume 13, Issue 19, Pages 5048-5051Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol201875q
Keywords
-
Categories
Ask authors/readers for more resources
The mild combination of T3P (n-propanephosphonic acid anhydride) and pyridine has been developed for low-epimerization amide bond formation and implemented for the synthesis of a key intermediate to a glucokinase activator. This robust method is general for the coupling of various racemization-prone acid substrates and amines, including relatively non-nucleophilic anilines, and provides amides in high yields with very low epimerization. With easy reaction setup and product isolation, this protocol offers several practical and experimental benefits.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available