4.8 Article

Consecutive Condensation, C-N and N-N Bond Formations: A Copper- Catalyzed One-Pot Three-Component Synthesis of 2H-Indazole

Journal

ORGANIC LETTERS
Volume 13, Issue 13, Pages 3542-3545

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol201409j

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Funding

  1. Korean Government [2009-0072357]
  2. National Research Foundation of Korea [과06B1512, 2009-0072357] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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2H-Indazoles are synthesized using copper-catalyzed, one-pot, three-component reactions of 2-bromobenzaldehydes, primary amines, and sodium azide. A copper catalyst plays the key role in the formation of C-N and N-N bonds. This method has a broad substrate scope with a high tolerance for a variety of functional groups.

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