4.8 Article

Pd-Catalyzed Desulfitative Heck Coupline with Dioxygen as the Terminal Oxidant

Journal

ORGANIC LETTERS
Volume 13, Issue 6, Pages 1432-1435

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol200101x

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Funding

  1. National Natural Science Foundation of China [20902076]
  2. Xiangtan University [09QDZI2]
  3. One Hundred Talent Project of Hunan Province

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A Pd-catalyzed desulfitative Heck-type reaction of aromatic sulfinic acid sodium salts with various olefins is developed with O-2 as the terminal oxidant under mild conditions. The presence of phosphane ligand DPEphos In anisole can significantly enhance the reaction selectivity.

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