4.8 Article

Synthesis of 3-Substituted Indazoles from Arynes and N-Tosylhydrazones

Journal

ORGANIC LETTERS
Volume 13, Issue 13, Pages 3340-3343

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol201086g

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Funding

  1. National Natural Science Foundation of China [21002021]
  2. Chinese Ministry of Education [210127]

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Readily available, stable, and inexpensive N-tosylhydrazones react with arynes under mild reaction conditions to afford 3-substituted indazoles in moderate to good yields. The reaction appears to involve a dipolar cycloaddition of in situ generated diazo compounds and arynes.

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