Journal
ORGANIC LETTERS
Volume 13, Issue 12, Pages 3214-3217Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol201122f
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Funding
- National Cancer Institute of the NIH [R01 CA101438]
- American Cancer Society [F-04-016-01-CDD]
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Regiocontrolled oxidative cyclizations of 3-substituted indoles are described herein. Specifically, it is shown that the installation of a chloride at C2 alters the Inherent propensity for cyclization at the 2-position of indole so as to favor the 4-position, enabling the construction of the unique framework found In most welwitindolinone alkaloids. The chloride functions here as more than a blocking group, as it also provides ready access to the corresponding oxindole.
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