4.8 Article

A Novel Synthesis of Fluorinated Pyrazoles via Gold(I)-Catalyzed Tandem Aminofluorination of Alkynes in the Presence of Selectfluor

Journal

ORGANIC LETTERS
Volume 13, Issue 16, Pages 4220-4223

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol201555z

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Funding

  1. Natural Science Foundation of Zhejiang Province [Y4100201]
  2. Foundation of Science and Technology Department of Zhejiang Province [2011R09002-09]
  3. Opening Foundation of Zhejiang Provincial Top Key Discipline

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A mild and efficient protocol for the synthesis of fluorinated pyrazoles has been developed via gold(I)-catalyzed tandem aminofluorination of alkynes in the presence of Selectfluor. This method offers a broad substrate scope.

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