Journal
ORGANIC LETTERS
Volume 13, Issue 5, Pages 928-931Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol102975t
Keywords
-
Categories
Funding
- Key New Drug Creation and Manufacturing Program [2009ZX09103-102]
- National High Technology Research and Development Program of China [2011AA10A207]
- National Basic Research Program of China [2010CB126100]
- China 111 Project [B07023]
- Shanghai Leading Academic Discipline Project [13507]
Ask authors/readers for more resources
Based on the hypoxia prodrug moiety of p-nitrobenzyl, a selective ratiometric fluorescent sensor (RHP) for the detection of microenvironment hypoxia was designed and synthesized. RHP can be selectively activated by bioreductive enzymes (NTR) and results in an evident blue to green fluorescent emission wavelength change in both solution phases and in cell lines, which might be the first fluorescent ratiometric probe for hypoxia in solid tumors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
