4.8 Article

Copper-Catalyzed Trifluoromethylation of Aryl and Vinyl Boronic Acids with An Electrophilic Trifluoromethylating Reagent

Journal

ORGANIC LETTERS
Volume 13, Issue 9, Pages 2342-2345

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol2005903

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Funding

  1. National Natural Science Foundation of China [21032006, 20632070]
  2. SIOCNational Basic Research Program of China [2010CB126103]

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A copper-catalyzed trifluoromethylation of aryl- and alkenylboronic acids with Togni's reagent was described. The reaction proceeded in good to excellent yields for a range of different substrates including heteroarylboronic acids and substrates with a variety of functional groups under mild reaction conditions.

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