Journal
ORGANIC LETTERS
Volume 13, Issue 16, Pages 4196-4199Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol201457y
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Funding
- National Natural Science Foundation of China [21072081]
- Fundamental Research Funds for the Central Universities [lzujbky-2009-81]
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A palladium-/copper-catalyzed intermolecular C-H amination reaction of indoles has been developed. This reaction proceeds in good to excellent yields to produce a variety of 2-amino-substituted indoles and exhibits excellent regioselectivity at room temperature. Furthermore, chloroamination of indoles provides a simple method for the construction of C-N and C-Cl bonds in one step.
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