4.8 Article

Catalyst-Free Preparation of 1,2,4,5-Tetrasubstituted Imidazoles from a Novel Unexpected Domino Reaction of 2-Azido Acrylates and Nitrones

Journal

ORGANIC LETTERS
Volume 13, Issue 24, Pages 6362-6365

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol202650z

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Funding

  1. Zhejiang University of Technology [56710108007]
  2. Science and Technology Project of Zhejiang Province [Y201121893]
  3. National Natural Science Foundation of China [21006095]
  4. Natural Science Foundation of Zhejiang Province [Y4100680]

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A highly efficient and convenient method for the synthesis of 1,2,4,5-tetrasubstituted imidazoles from readily accessible 2-azido acrylates and nitrones has been developed. This reaction proceeded under mild conditions without the assistance of any metal, acid, or base.

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