4.8 Article

Nickel-Catalyzed Selective Defluorination to Generate Partially Fluorinated Biaryls

Journal

ORGANIC LETTERS
Volume 13, Issue 10, Pages 2750-2753

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol200860t

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Funding

  1. University of British Columbia
  2. NSERC
  3. Canada Foundation for Innovation
  4. British Columbia Knowledge Development Fund
  5. AstraZeneca Canada

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A Ni-catalyzed, chemoselective cross-coupling reaction of polyfluoroarenes under mild reaction conditions is reported. A variety of fluorine-containing blaryls are synthesized in good-to-excellent yields. A wide range of substitution patterns and functional groups are tolerated.

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